The BCR gene recombines preferentially with Alu elements in complex BCR-ABL translocations of chronic myeloid leukaemia.

@article{Jeffs1998TheBG,
  title={The BCR gene recombines preferentially with Alu elements in complex BCR-ABL translocations of chronic myeloid leukaemia.},
  author={Aaron R. Jeffs and Suzanne M. Benjes and Thomas L. Smith and Stephen John Sowerby and Christine M. Morris},
  journal={Human molecular genetics},
  year={1998},
  volume={7 5},
  pages={
          767-76
        }
}
Chronic myeloid leukaemia (CML) develops when two genes, BCR on chromosome 22 and ABL on chromosome 9, recombine to form a hybrid BCR-ABL gene with leukaemogenic properties. The mechanism which underlies this recombination is unknown, but additional chromosome sites may be involved to form complex BCR-ABL rearrangements. The majority of breakpoints in BCR occur within a 5 kb major breakpoint cluster region, M-Bcr. Here, we show that the 3' part of M-Bcr recombined within, or immediately… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 57 CITATIONS

FILTER CITATIONS BY YEAR

1999
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

  • Averaged 2 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

Similar Papers

Loading similar papers…