The BCR gene encodes a novel serine/threonine kinase activity within a single exon.

@article{Maru1991TheBG,
  title={The BCR gene encodes a novel serine/threonine kinase activity within a single exon.},
  author={Yoshiro Maru and Owen N Witte},
  journal={Cell},
  year={1991},
  volume={67 3},
  pages={459-68}
}
Sequences encoded by the first exon of BCR that bind to the ABL SH2 domain are essential for the activation of the ABL tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene. The normal cellular BCR gene encodes a 160,000 dalton phosphoprotein associated with a serine/threonine kinase activity, but it shows only weak dispersed homologies to protein kinases. p160c-BCR was purified to apparent homogeneity as an oligomer of greater than 600,000 daltons that contains… CONTINUE READING
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