The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha.

  title={The BCR/ABL oncogene alters the chemotactic response to stromal-derived factor-1alpha.},
  author={Ravi Salgia and Elizabeth J. Quackenbush and Janine T. Lin and N Souchkova and Martin Sattler and Darren S Ewaniuk and Kevin M. Klucher and George Q. Daley and S K Kraeft and Robert Sackstein and E P Alyea and Ulrich H von Andrian and Lan Bo Chen and Jos{\'e} Carlos Guti{\'e}rrez-Ramos and Ann Marie Pendergast and James D Griffin},
  volume={94 12},
The chemokine stromal-derived factor-1alpha (SDF-1alpha) is a chemoattractant for CD34(+) progenitor cells, in vitro and in vivo. The receptor for SDF-1alpha, CXCR-4, is a 7 transmembrane domain receptor, which is also a coreceptor for human immunodeficiency virus (HIV). Here we show that transformation of hematopoietic cell lines by BCR/ABL significantly impairs their response to SDF-1alpha. Three different hematopoietic cell lines, Ba/F3, 32Dcl3, and Mo7e, were found to express CXCR-4 and to… CONTINUE READING


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