The BCL2 E17 and SP66 antibodies discriminate 2 immunophenotypically and genetically distinct subgroups of conventionally BCL2-"negative" grade 1/2 follicular lymphomas.

@article{Adam2013TheBE,
  title={The BCL2 E17 and SP66 antibodies discriminate 2 immunophenotypically and genetically distinct subgroups of conventionally BCL2-"negative" grade 1/2 follicular lymphomas.},
  author={P. Patterson Adam and Rosalie Baumann and Janine Schmidt and Sabrina Bettio and Katja Christina Weisel and Irina Bonzheim and Falko Fend and Leticia Quintanilla-Martinez},
  journal={Human pathology},
  year={2013},
  volume={44 9},
  pages={
          1817-26
        }
}
Follicular lymphoma (FL) is characterized by the translocation t(14;18)(q32;q21) resulting in constitutive overexpression of BCL2. However, in 10% to 15% of FL grade 1/2, immunohistochemical staining for BCL2 remains negative. To analyze the incidence of BCL2 negativity and the underlying molecular mechanisms in FL grade 1/2, BCL2 expression was investigated with 3 antibodies (clones 100D5, E17, SP66). The presence of a break in the BCL2 locus was determined by fluorescence in situ… CONTINUE READING
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