The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT

@article{Huynh1998TheBP,
  title={The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT},
  author={Khanh D. Huynh and Vivian J. Bardwell},
  journal={Oncogene},
  year={1998},
  volume={17},
  pages={2473-2484}
}
Virtually all diffuse large cell lymphomas and a significant fraction of follicular lymphomas contain translocations and/or point mutations in the 5′ non-coding region of the putative oncogene BCL-6, that are presumed to deregulate its expression. BCL-6 encodes a Cys2-His2 zinc finger transcriptional repressor with a POZ domain at its amino-terminus. The POZ (or BTB) domain, a 120-amino-acid motif, mediates homomeric and, in some proteins, heteromeric POZ-POZ interactions. In addition, the POZ… CONTINUE READING

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