The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes.

@article{Stumpf2013TheBI,
  title={The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes.},
  author={Melanie Stumpf and Xuyu Zhou and Jeffrey A Bluestone},
  journal={Journal of immunology},
  year={2013},
  volume={190 3},
  pages={961-9}
}
The critical role of CTLA-4 in inhibiting Ag-driven T cell responses upon engagement with its ligands, B7-1 and B7-2 and its importance for peripheral T cell tolerance and T cell homeostasis has been studied intensively. The CTLA-4 splice variant ligand-independent (li)-CTLA-4 is expressed in naive and activated T cells and can actively alter T cell… CONTINUE READING