The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.

@article{Young1992TheBA,
  title={The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.},
  author={J. Young and L. Koulova and S. Soergel and E. Clark and R. Steinman and B. Dupont},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 1},
  pages={
          229-37
        }
}
  • J. Young, L. Koulova, +3 authors B. Dupont
  • Published 1992
  • Biology, Medicine
  • The Journal of clinical investigation
  • T cells respond to peptide antigen in association with MHC products on antigen-presenting cells (APCs). A number of accessory or costimulatory molecules have been identified that also contribute to T cell activation. Several of the known accessory molecules are expressed by freshly isolated dendritic cells, a distinctive leukocyte that is the most potent APC for the initiation of primary T cell responses. These include ICAM-1 (CD54), LFA-3 (CD58), and class I and II MHC products. Dendritic… CONTINUE READING

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