The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.

@article{Young1992TheBA,
  title={The B7/BB1 antigen provides one of several costimulatory signals for the activation of CD4+ T lymphocytes by human blood dendritic cells in vitro.},
  author={James W Young and Lidia Koulova and Steve A. Soergel and Edward A. Clark and Ralph Marvin Steinman and B J Dupont},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 1},
  pages={229-37}
}
T cells respond to peptide antigen in association with MHC products on antigen-presenting cells (APCs). A number of accessory or costimulatory molecules have been identified that also contribute to T cell activation. Several of the known accessory molecules are expressed by freshly isolated dendritic cells, a distinctive leukocyte that is the most potent APC for the initiation of primary T cell responses. These include ICAM-1 (CD54), LFA-3 (CD58), and class I and II MHC products. Dendritic… CONTINUE READING
56 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 56 extracted citations

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…