The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation.

  title={The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation.},
  author={Michael R. Reid and W. Wang and K. Rosales and M. Welliver and Min Pan and M. Kong},
  journal={Molecular cell},
  volume={50 2},
  • Michael R. Reid, W. Wang, +3 authors M. Kong
  • Published 2013
  • Biology, Medicine
  • Molecular cell
  • Glutamine is an essential nutrient for cancer cell survival and proliferation, yet the signaling pathways that sense glutamine levels remain uncharacterized. Here, we report that the protein phosphatase 2A (PP2A)-associated protein, α4, plays a conserved role in glutamine sensing. α4 promotes assembly of an adaptive PP2A complex containing the B55α regulatory subunit via providing the catalytic subunit upon glutamine deprivation. Moreover, B55α is specifically induced upon glutamine deprivation… CONTINUE READING
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