The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replication.

@article{Uchiyama2004TheBO,
  title={The B-subunit of DNA polymerase alpha-primase associates with the origin recognition complex for initiation of DNA replication.},
  author={Masashi Uchiyama and Teresa S-F Wang},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 17},
  pages={7419-34}
}
The B-subunit (p70/Pol12p) of the DNA polymerase alpha-primase (Polalpha-primase) complex is thought to have a regulatory role in an early stage of S phase. We generated a panel of fission yeast thermosensitive mutants of the B-subunit (termed Spb70) to investigate its role in initiation of DNA replication by genetic and biochemical approaches. Here, we… CONTINUE READING