The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.

@article{Hudecek2010TheBT,
  title={The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.},
  author={Michael Hudecek and Thomas M Schmitt and Sivasubramanian Baskar and Maria Teresa Lupo-Stanghellini and Tetsuya Nishida and Tori N. Yamamoto and Marie E Bleakley and Cameron J Turtle and W. Chang and Harvey A Greisman and Brent M. Wood and David G Maloney and Michael C. Jensen and Christoph Rader and Stanley R Riddell},
  journal={Blood},
  year={2010},
  volume={116 22},
  pages={4532-41}
}
Monoclonal antibodies and T cells modified to express chimeric antigen receptors specific for B-cell lineage surface molecules such as CD20 exert antitumor activity in B-cell malignancies, but deplete normal B cells. The receptor tyrosine kinase-like orphan receptor 1 (ROR1) was identified as a highly expressed gene in B-cell chronic lymphocytic leukemia (B-CLL), but not normal B cells, suggesting it may serve as a tumor-specific target for therapy. We analyzed ROR1-expression in normal… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 92 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…