The B cell system in the rheumatoid inflammation

@article{Natvig1989TheBC,
  title={The B cell system in the rheumatoid inflammation},
  author={Jacob B. Natvig and Ingrid Randen and Keith Joseph Thompson and {\O}ystein Torleiv F{\o}rre and Eimar Munthe},
  journal={Springer Seminars in Immunopathology},
  year={1989},
  volume={11},
  pages={301-313}
}
RA is an immunological disorder characterized by a genetic predisposition related to HLA DR4 (Dw4, Dw14 and Dw15) and DR1 antigen-presenting molecules. The disease processes result from an immune response due to interaction between these genetically determined antigen-presenting HLA class II molecules on accessory cells and T helper cells. This gives rise to a strong delayed-type hypersensitivity reaction and a T helper cell-induced B cell proliferation with RF production, which in turn may… CONTINUE READING
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