The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction.

@article{John2003TheBC,
  title={The B cell coreceptor CD22 associates with AP50, a clathrin-coated pit adapter protein, via tyrosine-dependent interaction.},
  author={BinuJoy John and Brantley R Herrin and Chander Raman and Yan-ni Wang and Kevin R. Bobbitt and Brian A. Brody and Louis B. Justement},
  journal={Journal of immunology},
  year={2003},
  volume={170 7},
  pages={3534-43}
}
The B cell coreceptor CD22 plays an important role in regulating signal transduction via the B cell Ag receptor. Studies have shown that surface expression of CD22 can be modulated in response to binding of ligand (i.e., mAb). Thus, it is possible that alterations in the level of CD22 expression following binding of natural ligand(s) may affect its ability to modulate the Ag receptor signaling threshold at specific points during B cell development and differentiation. Therefore, it is important… CONTINUE READING

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