The B Cell SH2/PH Domain-Containing Adaptor Bam32/DAPP1 Is Required for T Cell-Independent II Antigen Responses

Abstract

BACKGROUND Bam32/DAPP1 is a B cell adaptor composed of both a PH and an SH2 domain. Previous studies in cell culture and chicken DT40 cells have indicated that Bam32 is critical for normal signaling downstream of the B cell receptor (BCR). RESULTS We now study the function of Bam32 in mice in which Bam32 has been disrupted by a viral gene trap approach… (More)
DOI: 10.1016/j.cub.2003.09.034

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