The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development.

@article{Park2009TheAP,
  title={The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development.},
  author={Il-kyoo Park and Chiara Giovenzana and Tiffany Hughes and Jianhua Yu and Rossana Trotta and Michael A. Caligiuri},
  journal={Blood},
  year={2009},
  volume={113 11},
  pages={2470-7}
}
Interleukin-15 (IL-15) is essential for natural killer (NK) cell differentiation. In this study, we assessed whether the receptor tyrosine kinase Axl and its ligand, Gas6, are involved in IL-15-mediated human NK differentiation from CD34(+) hematopoietic progenitor cells (HPCs). Blocking the Axl-Gas6 interaction with a soluble Axl fusion protein (Axl-Fc) or the vitamin K inhibitor warfarin significantly diminished the absolute number and percentage of CD3(-)CD56(+) NK cells derived from human… CONTINUE READING

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