The Atypical Cadherin Dachsous Controls Left-Right Asymmetry in Drosophila.

@article{GonzlezMorales2015TheAC,
  title={The Atypical Cadherin Dachsous Controls Left-Right Asymmetry in Drosophila.},
  author={Nicanor Gonz{\'a}lez-Morales and Charles G{\'e}minard and Ga{\"e}lle Lebreton and Delphine C{\'e}r{\'e}zo and J B Coutelis and St{\'e}phane Noselli},
  journal={Developmental cell},
  year={2015},
  volume={33 6},
  pages={675-89}
}
Left-right (LR) asymmetry is essential for organ development and function in metazoans, but how initial LR cue is relayed to tissues still remains unclear. Here, we propose a mechanism by which the Drosophila LR determinant Myosin ID (MyoID) transfers LR information to neighboring cells through the planar cell polarity (PCP) atypical cadherin Dachsous (Ds). Molecular interaction between MyoID and Ds in a specific LR organizer controls dextral cell polarity of adjoining hindgut progenitors and… CONTINUE READING
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