The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice.

@article{Sou2008TheAC,
  title={The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice.},
  author={Yu-shin Sou and Satoshi Waguri and Jun-ichi Iwata and Takashi Ueno and Tsutomu Fujimura and Taichi Hara and Naoki Sawada and Akane Yamada and Noboru Mizushima and Yasuo Uchiyama and Eiki Kominami and Keiji Tanaka and M. Asaliaru Komatsu},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 11},
  pages={
          4762-75
        }
}
Autophagy is an evolutionarily conserved bulk-protein degradation pathway in which isolation membranes engulf the cytoplasmic constituents, and the resulting autophagosomes transport them to lysosomes. Two ubiquitin-like conjugation systems, termed Atg12 and Atg8 systems, are essential for autophagosomal formation. In addition to the pathophysiological roles of autophagy in mammals, recent mouse genetic studies have shown that the Atg8 system is predominantly under the control of the Atg12… CONTINUE READING
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