The Ataxia-telangiectasia mutated gene and breast cancer: gene expression profiles and sequence variants.

Abstract

The role of the Ataxia-telangiectaisa mutated (ATM) gene, as a risk factor for breast cancer has been a consistent theme in the literature since the first reports by Swift and colleagues who reported that ATM heterozygotes in AT families had increased risks of developing breast cancer. Loss of heterozygosity at the ATM locus has been reported in 30-40% of breast tumours and 50-70% show altered ATM protein levels. Germline ATM sequence variants have been reported in breast cancer cases, however, it is difficult to fully evaluate the increased risk associated with their presence. The potential role of such variants needs to be further assessed, together with functional studies to model their impact on ATM function.

Statistics

050100'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

214 Citations

Semantic Scholar estimates that this publication has 214 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Hall2005TheAM, title={The Ataxia-telangiectasia mutated gene and breast cancer: gene expression profiles and sequence variants.}, author={Janet E. Hall}, journal={Cancer letters}, year={2005}, volume={227 2}, pages={105-14} }