The Associations Between OPRM 1 and COMT Genotypes and Postoperative Pain, Opioid Use, and Opioid-Induced Sedation

@article{Henker2013TheAB,
  title={The Associations Between OPRM 1 and COMT Genotypes and Postoperative Pain, Opioid Use, and Opioid-Induced Sedation},
  author={Richard A Henker and Allison Lewis and Feng Dai and William R. Lariviere and Li Meng and Gary S. Gruen and Susan M. Sereika and Hans Christoph Pape and Ivan S. Tarkin and Indira Gowda and Yvette P Conley},
  journal={Biological Research For Nursing},
  year={2013},
  volume={15},
  pages={309 - 317}
}
Previous studies have associated mu-opioid receptor (OPRM1) genotype with pain and analgesia responses in postoperative and patient populations. This study investigates the role of catechol-O-methyltransferase (COMT) and OPRM1 genotypes in acute postoperative pain scores, opioid use, and opioid-induced sedation after surgical procedures for orthopedic trauma in an otherwise healthy patient population. Verbal pain/sedation scores, opioid use, and physiologic responses in the immediate… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

Catechol-O-methyltransferase and pain in rodents and humans

VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Genetics of perioperative pain management

VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

A clustering of injury behaviors

  • A. T. Sia, Y. Lim, +4 authors E. C. Tan
  • Journal of Trauma
  • 2008
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Detecting Genotyping Error Using Measures of Degree of Hardy-Weinberg Disequilibrium

VIEW 1 EXCERPT

A clustering of injury behaviors.

VIEW 1 EXCERPT