The Association of Early and Recent Psychosocial Life Stress With Leukocyte Telomere Length

  title={The Association of Early and Recent Psychosocial Life Stress With Leukocyte Telomere Length},
  author={Josine E. Verhoeven and Patricia van Oppen and Eli Puterman and Bernet M. Elzinga and Brenda W.J.H. Penninx},
  journal={Psychosomatic Medicine},
Objectives Chronic exposure to psychosocial stressors is related to worse somatic health. This association applies both to stressors early in life, such as childhood adversities, and more recent life stress, such as stressful life events. This study examined whether accelerated telomere shortening, as an indicator of cellular aging, might be an explanatory mechanism. Methods We examined whether childhood adversities and recent stressful life events were associated with shorter telomeres in 2936… 

Early and recent psychosocial stress and telomere length in older adults

The findings did not consistently confirm the hypothesis that psychosocial stress is associated with shorter telomere length in older adults, and healthy survivorship or other TL-damaging factors such as somatic health problems seem to dominate a potential effect of psychossocial stress on TL in Older adults.

Early life trauma and adult leucocyte telomere length

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Results imply that interventions should focus on establishing strong social connections, psychological resources, and health-maintaining behaviors when attempting to ameliorate stress-related decline in telomere length among at-risk individuals.

The association of individual changes in stressful life events and telomere length over time in twins aged 50 years and above.

The findings in an older population show a causal relation between increase in life stress on accelerated LTL shortening by using intra-individual time-varying analysis.

Cold parenting is associated with cellular aging in offspring: A retrospective study

Transcriptomic analyses and leukocyte telomere length measurement in subjects exposed to severe recent stressful life events

Data suggest an association between exposures to recent stressful life events in adulthood and alterations in the immune, inflammatory and oxidative stress pathways, which could be also involved in the negative effect of Stressful life events on leukocyte telomere length.



Life stress, emotional health, and mean telomere length in the European Prospective Investigation into Cancer (EPIC)-Norfolk population study.

Evidence that adverse experiences during childhood may be associated with shorter telomere length is found and this finding remained after covariate adjustment and showed evidence of a dose-response relationship with increasing number of reported childhood difficulties associated with decreasing relative mean telomeres length.

Childhood Adversity Heightens the Impact of Later-Life Caregiving Stress on Telomere Length and Inflammation

Adverse childhood events are related to continued vulnerability among older adults, enhancing the impact of chronic stressors.

Telomere Length, Current Perceived Stress, and Urinary Stress Hormones in Women

The findings suggest the effect of stress on telomere length may vary depending on neuroendocrine responsiveness, external stressors, and age.

Telomeres and Early-Life Stress: An Overview

Childhood Adversities Are Associated with Shorter Telomere Length at Adult Age both in Individuals with an Anxiety Disorder and Controls

The results suggest that childhood stress might lead to accelerated telomere shortening seen at the adult age, and has potentially important implications supporting the view that childhood adversities might have a considerable impact on well being later in life.

An intricate dance: Life experience, multisystem resiliency, and rate of telomere decline throughout the lifespan.

It is suggested that chronic stress effects can be best understood by directly testing if the deleterious effects of stress on biological aging processes are mitigated in individuals with high levels of multisystem resiliency.

Early life stress and telomere length: Investigating the connection and possible mechanisms

  • I. Shalev
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    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2012
The current state of the science is covered and new research directions are laid out in order to translate telomere discoveries into clinical applications for monitoring health and predicting disease risk.

The Power of Exercise: Buffering the Effect of Chronic Stress on Telomere Length

Vigorous physical activity appears to protect those experiencing high stress by buffering its relationship with TL, and a proposed pathways through which physical activity acts to buffer stress effects is proposed.