The Association of C-Reactive Protein and CRP Genotype with Coronary Heart Disease: Findings from Five Studies with 4,610 Cases amongst 18,637 Participants

@article{Lawlor2008TheAO,
  title={The Association of C-Reactive Protein and CRP Genotype with Coronary Heart Disease: Findings from Five Studies with 4,610 Cases amongst 18,637 Participants},
  author={Debbie A Lawlor and Roger M. Harbord and Nicholas J. Timpson and Gordon D. O. Lowe and Ann Rumley and Tom R. Gaunt and Ian D Baker and John W. G. Yarnell and Mika Kivim{\"a}ki and Meena Kumari and Paul E. Norman and Konrad Jamrozik and Graeme J. Hankey and Osvaldo P. Almeida and Leon Flicker and Nicole M. Warrington and Michael Marmot and Yoav Ben-Shlomo and Lyle John Palmer and I. N. Day and Shah Ebrahim and George Davey Smith},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={730 - 733}
}
BACKGROUND It is unclear whether C-reactive protein (CRP) is causally related to coronary heart disease (CHD). Genetic variants that are known to be associated with CRP levels can be used to provide causal inference of the effect of CRP on CHD. Our objective was to examine the association between CRP genetic variant +1444C>T (rs1130864) and CHD risk in the largest study to date of this association. METHODS AND RESULTS We estimated the association of CRP genetic variant +1444C>T (rs1130864… CONTINUE READING
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