The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence

  title={The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence},
  author={Chin-Chi Kuo and Katherine A. Moon and Shu-Li Wang and Ellen Kovner Silbergeld and Ana Navas-Acien},
  journal={Environmental Health Perspectives},
Background: The available evidence on the role of arsenic metabolism in individual susceptibility to the development of cancer, cardiovascular disease, and diabetes has not been formally and comprehensively reviewed. Objectives: Our goal was to systematically investigate the association of arsenic metabolism with cancer, cardiovascular disease, and diabetes-related outcomes in epidemiologic studies. As a secondary objective, we characterized the variation of arsenic metabolism in different… 

A Clinical Perspective on Arsenic Exposure and Development of Atherosclerotic Cardiovascular Disease

The existing data of low-to-moderate dose iAs exposure and its effect on CVD are reviewed, along with highlighting the potential mechanisms of action.

The Association of Arsenic Exposure and Arsenic Metabolism With the Metabolic Syndrome and Its Individual Components: Prospective Evidence From the Strong Heart Family Study

Arsenic metabolism, specifically lower percentage of monomethylarsonic acid and higher percentage of dimethylarsinic acid, was associated with higher risk of overall MetS and elevated waist circumference but not with any other MetS component.

Arsenic Exposure and Risk of Urothelial Cancer: Systematic Review and Meta-Analysis

Arsenic metabolites are significantly associated to urothelial cancer, according to a systematic review of observational studies that evaluated the association of arsenic metabolites and urinary tract cancer.

Association between Arsenic Exposure and Cardiovascular Disease.

There are a substantial amount of retrospective and prospective cohort studies supporting the role of arsenic in CVD, although randomized controlled trials have yet to be conducted and the need for future research is evaluated.

Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of the Potential Mechanisms

The existing evidence of the multiple mechanisms triggered by arsenic to developing the cardinal signs of MS is summarized, showing that this pollutant could contribute to the multifactorial origin of this pathology.

Gender Differences in the Risk of Metabolic Syndrome Among Chronic Arsenic-Exposed Individuals in Bangladesh

The higher risk of arsenic-related MeS in women than in men suggests a greater susceptibility of women to CVDs that warrant more future investigations on the gender-based distinct pathophysiologic mechanisms of arsenic -related CVDS and diabetes.



Arsenic Exposure and Cardiovascular Disease:An Updated Systematic Review

The evidence for a causal association between high-chronic arsenic exposure and clinical cardiovascular endpoints is strengthened and additional high quality studies are needed at low-moderate arsenic levels.

A Prospective Study of Arsenic Exposure, Arsenic Methylation Capacity, and Risk of Cardiovascular Disease in Bangladesh

Arsenic exposure from drinking water and the incomplete methylation capacity of arsenic were adversely associated with heart disease risk and there was some evidence of a synergy of incompletemethylation capacity with older age and cigarette smoking.

Environmental Chemicals and Type 2 Diabetes: An Updated Systematic Review of the Epidemiologic Evidence

The evidence is suggestive but not sufficient for a relationship between arsenic and persistent organic pollutants and is insufficient for mercury, phthalates, and bisphenol A.

Interaction between Arsenic Exposure from Drinking Water and Genetic Polymorphisms on Cardiovascular Disease in Bangladesh: A Prospective Case-Cohort Study

Observations between CVD and arsenic exposure may be modified by genetic variants related to endothelial dysfunction, and interaction between arsenic exposure from drinking water and genetic polymorphisms on cardiovascular disease in Bangladesh is investigated.

Polymorphisms in arsenic metabolism genes, urinary arsenic methylation profile and cancer

Arsenic-metabolism-related genes can regulate the arsenic methylation process and may influence susceptibility to cancer. We evaluated the roles of arsenic metabolism genes on urinary arsenic

Chronic Exposure to Arsenic and Markers of Cardiometabolic Risk: A Cross-Sectional Study in Chihuahua, Mexico

In this cohort, As exposure was associated with several markers of increased cardiometabolic risk (diabetes, triglyceridemia, and cholesterolemia), but exposure was also associated with higher rather than lower HDL cholesterol.

Determinants and Consequences of Arsenic Metabolism Efficiency among 4,794 Individuals: Demographics, Lifestyle, Genetics, and Toxicity

Two distinct arsenic metabolism phenotypes show unique associations with age, sex, BMI, 10q24.32 polymorphisms, and skin lesions, which enhances the understanding of arsenic metabolism kinetics and toxicity risk profiles.

Interactions between arsenic-induced toxicity and nutrition in early life.

  • M. Vahter
  • Medicine
    The Journal of nutrition
  • 2007
There seems to be a wide variation in susceptibility to arsenic toxicity, which is likely to be related to factors such as variation in arsenic metabolism, nutrition, host-related defense mechanisms, and genetic predisposition.