The Association between Polymorphisms in the CYP 17 and 5 a-Reductase ( SRD 5 A 2 ) Genes and Serum Androgen Concentrations in Men 1

@inproceedings{Allen2001TheAB,
  title={The Association between Polymorphisms in the CYP 17 and 5 a-Reductase ( SRD 5 A 2 ) Genes and Serum Androgen Concentrations in Men 1},
  author={Naomi E. Allen and Matthew S. Forrest and Timothy J Key},
  year={2001}
}
Prospective studies suggest that prostate cancer risk may be increased in association with high serum concentrations of free testosterone and androstanediol glucuronide (A-diol-g). Polymorphisms have been identified in the 17-hydroxylase cytochrome P450 gene (CYP17) and the steroid 5a-reductase type II gene (SRD5A2), two genes that are involved in the biosynthesis and metabolism of androgens in men. TheCYP17 MspA1 I polymorphism has been associated with increased prostate cancer risk, and… CONTINUE READING
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