The Association Between Depression and Isotretinoin Use in Acne

@article{HongNg2003TheAB,
  title={The Association Between Depression and Isotretinoin Use in Acne},
  author={Chee Hong Ng and Isaac Schweitzer},
  journal={Australian and New Zealand Journal of Psychiatry},
  year={2003},
  volume={37},
  pages={78 - 84}
}
Objective: The association between isotretinoin and depression has received little attention in the psychiatric literature despite an increasing number of reports in medical journals. The purpose of this paper is to highlight this association, examine the possible link and review the clinical implications. Method: A critical review of the literature pertaining to depression in patients with acne who were treated with isotretinoin was conducted. Results and Conclusions: The causal relationship… Expand
Evaluation of depressive symptoms in acne patients treated with isotretinoin
TLDR
The results provide no relationship between isotretinoin use and depression in acne patients and Improvement in anxiety was detected later than the improvement in depressive symptoms and a statistically significant difference was detected between the first and the second follow-up. Expand
No association found between patients receiving isotretinoin for acne and the development of depression in a Canadian prospective cohort.
TLDR
Isotretinoin does not appear to be associated with the development of depression, and denying patients with significant acne an effective medication for fear of developing depression may not be indicated at this point in time. Expand
Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review.
TLDR
The current literature does not support a causative association between isotretinoin use and depression, and there are important limitations to many of the studies. Expand
Depression and suicidal behavior in acne patients treated with isotretinoin: a systematic review.
TLDR
The current literature does not support a causative association between isotretinoin use and depression, and there are important limitations to many of the studies. Expand
Isotretinoin and psychiatric side effects: facts and hypothesis
TLDR
It appears today that the link between suicides and severe depressions has not yet been clearly demonstrated, and one of the hypotheses could be that these psychiatric side effects are unpredictable idiosyncratic phenomena. Expand
Isotretinoin: controversies, facts, and recommendations
TLDR
There is weak evidence for increased incidence of depression, suicidality, or inflammatory bowel disease with isotretinoin use, and data indicates that transient increases in transaminases and lipid levels do not typically necessitate discontinuation of therapy. Expand
Acne, depression, and suicide.
TLDR
It is prudent for the practitioner to continue to use isotretinoin to treat severe acne, while informing patients and their relatives that depressive symptoms should be actively assessed at each visit and, if necessary, referral to a psychiatrist and a discontinuation of isot retinoin should be considered. Expand
The Effect of Isotretinoin (Roaccutane) Therapy on Depression and Quality of Life of Patients with Severe Acne
TLDR
Isotretinoin therapy improved the quality of life of patients suffering from acne, but depression was accentuated in the patients to some extent. Expand
Psychiatric reactions to isotretinoin in patients with bipolar disorder.
TLDR
BD patients treated with isotretinoin for acne are at risk for clinically significant exacerbation of mood symptoms, including suicidal ideation, even with concurrent use of psychiatric medicines for BD. Expand
Isotretinoin and depression: more than skin deep?
TLDR
Factors that support a possible association between isotretinoin and depression are a temporal association between use of the drug and depression, positive dechallenges (often with psychiatric treatment), and positive rechallenges. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 39 REFERENCES
Isotretinoin therapy and depression – evidence for an association
TLDR
The indications suggest that there appears to be an association between depression and the recent use of isotretinoin, which may relate to the ability of isot retinoin to simulate hypovitaminosis A, with aggression, irritability and depression as a direct result of this effect. Expand
Case Report/Case Series:Acne, Isotretinoin Treatment and Acute Depression
  • C. Ng, Mei Mui Tarn, S. Hook
  • Medicine
  • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2001
The association between isotretinoin therapy and depressive symptoms in acne patients has generated much recent interest but has not been systematically explored. A 17-year-old man with acne vulgarisExpand
Isotretinoin Use in Acne: Prospective Evaluation of Adverse Events
TLDR
This prospective analysis has shown that patients treated with isotretinoin experienced a predictable series of side effects, some occurred fleetingly, but several persisted for the duration of treatment. Expand
Prospective study of depressive symptoms and quality of life in acne vulgaris patients treated with isotretinoin compared to antibiotic and topical therapy
TLDR
This pilot study does not appear to support any direct link between depression and isotretinoin, apart from being a rare unpredictable idiosyncratic side‐effect, and because of the study limitations, a larger study is needed to confirm the findings. Expand
Reduced anxiety and depression in cystic acne patients after successful treatment with oral isotretinoin.
TLDR
Significant reductions in anxiety were observed on several measures of anxiety after treatment, with mitigation of anxiety and depression most robust in those patients with the greatest dermatologic improvement with isotretinoin. Expand
The psychological and emotional impact of acne and the effect of treatment with isotretinoin
TLDR
Treatment with isotretinoin produced significant improvements across a wide variety of psychological functions, although the emotional status of patients appeared to be more resistant to change. Expand
An analysis of reports of depression and suicide in patients treated with isotretinoin.
TLDR
Doctors are advised to inform patients prescribed isotretinoin of the possibility of development or worsening of depression and to advise patients to immediately report mood swings and symptoms suggestive of depression so that patients can be promptly evaluated for appropriate treatment. Expand
Isotretinoin use and risk of depression, psychotic symptoms, suicide, and attempted suicide.
TLDR
This study provides no evidence that use of isotretinoin is associated with an increased risk for depression, suicide, or other psychiatric disorders. Expand
Long‐term safety of isotretinoin as a treatment for acne vulgaris
TLDR
The findings of this study indicate that isotretinoin in the treatment of acne is a safe drug, with no serious long‐term side‐effects. Expand
Adverse reactions to isotretinoin. A report from the Adverse Drug Reaction Reporting System.
TLDR
Spontaneous reports of adverse reactions associated with isotretinoin use, together with the literature the authors review, may help alert physicians to the diverse spectrum of adverse reaction that may develop in patients taking isot retinoin. Expand
...
1
2
3
4
...