The Assembly Pathway of Mitochondrial Respiratory Chain Complex I.

  title={The Assembly Pathway of Mitochondrial Respiratory Chain Complex I.},
  author={Sergio Guerrero-Castillo and F Baertling and Daniel Kownatzki and Hans J. C. T. Wessels and S. Arnold and Ulrich Brandt and Leo G. J. Nijtmans},
  journal={Cell metabolism},
  volume={25 1},
Mitochondrial complex I is the largest integral membrane enzyme of the respiratory chain and consists of 44 different subunits encoded in the mitochondrial and nuclear genome. Its biosynthesis is a highly complicated and multifaceted process involving at least 14 additional assembly factors. How these subunits assemble into a functional complex I and where the assembly factors come into play is largely unknown. Here, we applied a dynamic complexome profiling approach to elucidate the assembly… CONTINUE READING
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