The Aspergillus niger GCN4 homologue, cpcA, is transcriptionally regulated and encodes an unusual leucine zipper.

@article{Wanke1997TheAN,
  title={The Aspergillus niger GCN4 homologue, cpcA, is transcriptionally regulated and encodes an unusual leucine zipper.},
  author={Christoph Martin Wanke and Saskia Eckert and Genevi{\`e}ve Albrecht and W van Hartingsveldt and Peter Jan Punt and Cees Amjj van den Hondel and Gerhard H Braus},
  journal={Molecular microbiology},
  year={1997},
  volume={23 1},
  pages={
          23-33
        }
}
The general control transcriptional regulator gene cpcA of Aspergillus niger was cloned by complementation of a Saccharomyces cerevisiae delta gcn4 mutant strain. The encoded protein conferred resistance to amino acid analogues when expressed in yeast. Disruption of cpcA in A. niger resulted in a strain which is sensitive towards 3-aminotriazole and fails to respond to amino acid starvation, cpcA encodes a transcript of approximately 2400 nucleotides in length that includes a 5' leader region… CONTINUE READING
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