The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones.

@article{Schneider2008TheAN,
  title={The Aspergillus nidulans enzyme TdiB catalyzes prenyltransfer to the precursor of bioactive asterriquinones.},
  author={Patrick Schneider and M. H. Unsworth W. Urbach IA. Weber and D. C. Hoffmeister},
  journal={Fungal genetics and biology : FG & B},
  year={2008},
  volume={45 3},
  pages={302-9}
}
The asterriquinones represent a class of ascomycete metabolic products whose significance stems from remarkable and useful pharmacological activities, among those antiretroviral (e.g., against the HI-virus), antitumor, and antidiabetes properties. Recently, the first genetic locus for an asterriquinone, the clustered terrequinone genes tdiA-E, was identified during a genome-wide screen in Aspergillus nidulans for "orphan" natural product biosynthesis loci. Here, we describe overexpression and… CONTINUE READING

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