The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen.

@article{Krappmann2004TheAF,
  title={The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen.},
  author={Sven Krappmann and Elaine M Bignell and Utz Reichard and Tom Rogers and Ken Haynes and Gerhard H Braus},
  journal={Molecular microbiology},
  year={2004},
  volume={52 3},
  pages={785-99}
}
We have cloned and characterized the Aspergillus fumigatus cpcA gene encoding the transcriptional activator of the cross-pathway control system of amino acid biosynthesis. cpcA encodes a functional orthologue of Saccharomyces cerevisiae Gcn4p. The coding sequence of the 2.2 kb transcript is preceded by two short upstream open reading frames, the larger one being well conserved among Aspergilli. Deletion strains in which either the coding sequence or the entire locus are replaced by a… CONTINUE READING