The Aryl hydrocarbon receptor: an illuminating effector of the UVB response.

@article{Agostinis2007TheAH,
  title={The Aryl hydrocarbon receptor: an illuminating effector of the UVB response.},
  author={Patrizia Agostinis and Marjan Garmyn and An Van Laethem},
  journal={Science's STKE : signal transduction knowledge environment},
  year={2007},
  volume={2007 403},
  pages={pe49}
}
The aryl hydrocarbon receptor (AhR) is a cytosolic ligand-activated transcription factor that mediates most of the toxic and carcinogenic effects of drugs and environmental toxins collectively known as xenobiotics. Ligand activation of the AhR stimulates the transcription of genes that encode several xenobiotic-metabolizing enzymes. The molecular mechanisms and signaling pathways evoked by the activation of the AhR are becoming increasingly understood and underscore the participation of the AhR… CONTINUE READING