The Aryl hydrocarbon Receptor (AhR) interacts with c-Maf to promote the differentiation of IL-27-induced regulatory type 1 (TR1) cells

@inproceedings{Apetoh2010TheAH,
  title={The Aryl hydrocarbon Receptor (AhR) interacts with c-Maf to promote the differentiation of IL-27-induced regulatory type 1 (TR1) cells},
  author={Lionel Apetoh and Francisco J. Quintana and Caroline Pot and Nicole Joller and Sheng Xiao and Deepak Kumar Vijaya Kumar and Evan J. Burns and David H. Sherr and Howard L. Weiner and Vijay K Kuchroo},
  booktitle={Nature Immunology},
  year={2010}
}
Type 1 regulatory T cells (Tr1 cells ) that produce interleukin 10 (IL-10) are instrumental in the prevention of tissue inflammation, autoimmunity and graft-versus-host disease. The transcription factor c-Maf is essential for the induction of IL-10 by Tr1 cells, but the molecular mechanisms that lead to the development of these cells remain unclear. Here we… CONTINUE READING