The Aryl Hydrocarbon Receptor Influences Transplant Outcomes in Response to Environmental Signals.

@article{Pauly2012TheAH,
  title={The Aryl Hydrocarbon Receptor Influences Transplant Outcomes in Response to Environmental Signals.},
  author={Sebastian Pauly and John J H Fechner and Xiaoji Zhang and Jose Ignacio Torrealba and Christopher A. Bradfield and Joshua D. Mezrich},
  journal={Toxicological and environmental chemistry},
  year={2012},
  volume={94 6},
  pages={1175-1187}
}
The aryl hydrocarbon receptor (AHR) is a cytosolic transcription factor with numerous endogenous and xenobiotic ligands, most notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Recent data suggests that TCDD may induce regulatory T cells, while a second AHR ligand, FICZ, promotes Th17 differentiation. The aim was to examine whether injection of recipient mice with either TCDD or FICZ altered skin allograft rejection in a fully mismatched model. TCDD or FICZ was given to recipient C57BL/6 mice… CONTINUE READING