The Aryl Hydrocarbon Receptor: A Target for Breast Cancer Therapy

  title={The Aryl Hydrocarbon Receptor: A Target for Breast Cancer Therapy},
  author={Joann B Powell and Gennifer D. Goode and Sakina E. Eltom},
  booktitle={Journal of cancer therapy},
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates a battery of genes in response to exposure to a broad class of environmental poly aromatic hydrocarbons (PAH). AhR is historically characterized for its role in mediating the toxicity and adaptive responses to these chemicals, however mounting evidence has established a role for it in ligand-independent physiological processes and pathological conditions, including cancer. The AhR is overexpressed and… CONTINUE READING
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