The ArsD As(III) metallochaperone

@article{Ajees2010TheAA,
  title={The ArsD As(III) metallochaperone},
  author={A. Abdul Ajees and Jian-bo Yang and Barry P. Rosen},
  journal={BioMetals},
  year={2010},
  volume={24},
  pages={391-399}
}
Arsenic, a toxic metalloid widely existing in the environment, causes a variety of health problems. The ars operon encoded by Escherichia coli plasmid R773 has arsD and arsA genes, where ArsA is an ATPase that is the catalytic subunit of the ArsAB As(III) extrusion pump, and ArsD is an arsenic chaperone for ArsA. ArsD transfers As(III) to ArsA and increases the affinity of ArsA for As(III), allowing resistance to environmental concentrations of arsenic. Cys12, Cys13 and Cys18 in ArsD form a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Genetic mapping of the interface between the ArsD metallochaperone and the ArsA ATPase

  • J Yang, A Abdul Ajees, BP Rosen
  • Mol Microbiol
  • 2011

Step 2 As(III)-bound ArsD binds to the open form of ArsA. Step 3 As(III) is transferred in a step-wise

  • Ye
  • 2010

Similar Papers

Loading similar papers…