The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes

@article{May1999TheAC,
  title={The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes},
  author={Robin C May and Margaret E. Hall and Henry N Higgs and Thomas D. Pollard and Trinad Chakraborty and J{\"u}rgen Wehland and Laura M Machesky and Antonio S. Sechi},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={759-762}
}
Actin polymerisation is thought to drive the movement of eukaryotic cells and some intracellular pathogens such as Listeria monocytogenes. The Listeria surface protein ActA synergises with recruited host proteins to induce actin polymerisation, propelling the bacterium through the host cytoplasm [1]. The Arp2/3 complex is one recruited host factor [2] [3]; it is also believed to regulate actin dynamics in lamellipodia [4] [5]. The Arp2/3 complex promotes actin filament nucleation in vitro… CONTINUE READING