The Aromatase Cytochrome P-450 and Its Clinical Impact

@article{Meinhardt2002TheAC,
  title={The Aromatase Cytochrome P-450 and Its Clinical Impact},
  author={Udo J. Meinhardt and Primus E. Mullis},
  journal={Hormone Research in Paediatrics},
  year={2002},
  volume={57},
  pages={145 - 152}
}
Cytochrome P-450 aromatase (P450arom), the key enzyme for estrogen biosynthesis, is encoded by a single gene, namely the CYP19 gene, localized on 15q21.2. The human CYP19 gene spans about 123 kb with a coding region of 9 exons (about 30 kb, exon II–exon X). Although there are a number of alternative first exons and nine different transcriptional start sides with individual promoters that permit tissue-specific regulation of expression, the protein expressed in these various tissue sites… Expand
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