The Arl4 Family of Small G Proteins Can Recruit the Cytohesin Arf6 Exchange Factors to the Plasma Membrane

@article{Hofmann2007TheAF,
  title={The Arl4 Family of Small G Proteins Can Recruit the Cytohesin Arf6 Exchange Factors to the Plasma Membrane},
  author={I. Hofmann and A. Thompson and C. Sanderson and S. Munro},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={711-716}
}
  • I. Hofmann, A. Thompson, +1 author S. Munro
  • Published 2007
  • Biology, Medicine
  • Current Biology
  • The small GTPase Arf6 regulates endocytosis, actin dynamics, and cell adhesion, and one of its major activators is the exchange factor Arf nucleotide-binding site opener (ARNO), also called cytohesin-2 [1, 2]. ARNO must be recruited from the cytosol to the plasma membrane in order to activate Arf6, and in addition to a Sec7 nucleotide-exchange domain it contains a C-terminal pleckstrin homology (PH) domain that binds phosphoinositides [3, 4]. ARNO and its three relatives, cytohesin-1, Grp1… CONTINUE READING

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