The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation

@article{Claycomb2009TheAC,
  title={The Argonaute CSR-1 and Its 22G-RNA Cofactors Are Required for Holocentric Chromosome Segregation},
  author={Julie M. Claycomb and Pedro J. Batista and Ka Ming Pang and Weifeng Gu and Jessica J. Vasale and Josien C. van Wolfswinkel and Daniel A. Chaves and Masaki Shirayama and Shohei Mitani and Ren{\'e} F Ketting and Darryl Conte and Craig C. Mello},
  journal={Cell},
  year={2009},
  volume={139},
  pages={123-134}
}
RNAi-related pathways regulate diverse processes, from developmental timing to transposon silencing. Here, we show that in C. elegans the Argonaute CSR-1, the RNA-dependent RNA polymerase EGO-1, the Dicer-related helicase DRH-3, and the Tudor-domain protein EKL-1 localize to chromosomes and are required for proper chromosome segregation. In the absence of these factors chromosomes fail to align at the metaphase plate and kinetochores do not orient to opposing spindle poles. Surprisingly, the… CONTINUE READING

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