The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.

@article{Veland2017TheAM,
  title={The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.},
  author={Nicolas Veland and Swanand Hardikar and Yi Zhong and Sitaram Gayatri and Jiameng Dan and Brian D. Strahl and Scott B Rothbart and Mark T Bedford and Taiping Chen},
  journal={Cell reports},
  year={2017},
  volume={21 12},
  pages={
          3390-3397
        }
}
DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How DNA methylation is regulated in developmental and cellular processes and dysregulated in cancer is poorly understood. Here, we show that PRMT6, a protein arginine methyltransferase responsible for asymmetric dimethylation of histone H3 arginine 2… CONTINUE READING
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