The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines.

@article{Rose2004TheAB,
  title={The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines.},
  author={Karl La Ros{\'e}e and Michael Huntgeburth and Stephan Guido Rosenkranz and Michael B{\"o}hm and Petra Schnabel},
  journal={Pharmacogenetics},
  year={2004},
  volume={14 11},
  pages={
          711-6
        }
}
OBJECTIVES Recently, the Arg389Gly beta1-adrenoceptor (beta1AR) gene polymorphism has been detected. The Arg variant exhibited increased responsiveness to agonist-induced stimulation in vitro. Functional studies in isolated human atrial muscle strips and in-vivo studies revealed contradictory results regarding the functional relevance of this polymorphism. We sought to characterize the functional consequences of the Arg389Gly beta1-AR polymorphism in 30 consecutive healthy male volunteers in… CONTINUE READING
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