The Architecture of the Adhesive Apparatus of Cultured Osteoclasts: From Podosome Formation to Sealing Zone Assembly

@article{Luxenburg2007TheAO,
  title={The Architecture of the Adhesive Apparatus of Cultured Osteoclasts: From Podosome Formation to Sealing Zone Assembly},
  author={Chen Luxenburg and Dafna Geblinger and Eugenia Klein and Karen Ann Anderson and Dorit Hanein and Benjamin Geiger and Lia Addadi},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={271 - 298}
}
BACKGROUND Osteoclasts are bone-degrading cells, which play a central role in physiological bone remodeling. Unbalanced osteoclast activity is largely responsible for pathological conditions such as osteoporosis. Osteoclasts develop specialized adhesion structures, the so-called podosomes, which subsequently undergo dramatic reorganization into sealing zones. These ring-like adhesion structures, which delimit the resorption site, effectively seal the cell to the substrate forming a diffusion… CONTINUE READING

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