The Architecture of Cognitive Control in the Human Prefrontal Cortex

  title={The Architecture of Cognitive Control in the Human Prefrontal Cortex},
  author={Etienne Koechlin and Chryst{\`e}le Ody and F. Kouneiher},
  pages={1181 - 1185}
The prefrontal cortex (PFC) subserves cognitive control: the ability to coordinate thoughts or actions in relation with internal goals. Its functional architecture, however, remains poorly understood. Using brain imaging in humans, we showed that the lateral PFC is organized as a cascade of executive processes from premotor to anterior PFC regions that control behavior according to stimuli, the present perceptual context, and the temporal episode in which stimuli occur, respectively. The… 
Motivation and cognitive control in the human prefrontal cortex
The results indicate that motivation is a dissociable function, reveal how the PFC integrates motivation and cognitive control in the service of decision-making, and have major implications for current theories of prefrontal executive function.
Upper processing stages of the perception–action cycle
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Frontal Cortex and the Hierarchical Control of Behavior
Broca's Area and the Hierarchical Organization of Human Behavior
The gateway hypothesis of rostral prefrontal cortex (area 10) function
Cognitive and Motivational Functions of the Human Prefrontal Cortex
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Model of various aspects of control, including top-down processing, decision making, and performance monitoring focus primarily on two subdivisions of the PFC, namely, the dorsolateral prefrontal cortex (DLPFC) and the medial frontal cortex, particularly the anterior cingulate cortex (ACC).
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It is suggested that having separate control mechanisms based on local or global task features allows humans to be persistent in pursuing their goals, yet flexible enough to adapt to changes in the environment.


An integrative theory of prefrontal cortex function.
It is proposed that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them, which provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task.
The role of the anterior prefrontal cortex in human cognition
The results indicate that the fronto-polar prefrontal cortex selectively mediates the human ability to hold in mind goals while exploring and processing secondary goals, a process generally required in planning and reasoning.
Human prefrontal cortex: processing and representational perspectives
This paper argues for the validity of a representational approach to understanding PFC function and suggests that the prefrontal cortex underlies much of human higher cognition.
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Using functional MRI, a double dissociation is reported that supports the assumption that common frontal organizational principles underlie motor and higher executive functions in humans.
The prefrontal cortex: response selection or maintenance within working memory?
The results support a role for the dorsal prefrontal cortex in the selection of representations and accounts for the fact that this area is activated both when subjects select between items on working memory tasks and when they freely select between movements on tasks of willed action.
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The prospects for extending the approach to include a range of other executive processes, and to the way in which such an analysis may subsequently lead to a more integrated model of the central executive, and a better understanding of its relationship to the prefrontal cortex are discussed.
Prefrontal interactions reflect future task operations
By introducing a delay between the instruction and the task, the neural correlates of task sets are identified using functional magnetic resonance imaging (fMRI) and inter-regional interactions that reflect preparation for task performance are identified.
Neurobiology of Decision-Making
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