The Arabidopsis TDS4 gene encodes leucoanthocyanidin dioxygenase (LDOX) and is essential for proanthocyanidin synthesis and vacuole development.

@article{Abrahams2003TheAT,
  title={The Arabidopsis TDS4 gene encodes leucoanthocyanidin dioxygenase (LDOX) and is essential for proanthocyanidin synthesis and vacuole development.},
  author={Sharon Abrahams and Elizabeth Lee and Amanda R Walker and Gregory J. Tanner and Philip J. Larkin and Anthony R. Ashton},
  journal={The Plant journal : for cell and molecular biology},
  year={2003},
  volume={35 5},
  pages={624-36}
}
The anthocyanin and proanthocyanidin (PA) biosynthetic pathways share common intermediates until leucocyanidin, which may be used by leucoanthocyanidin dioxygenase (LDOX) to produce anthocyanin, or the enzyme leucoanthocyanidin reductase (LAR) to produce catechin, a precursor of PA. The Arabidopsis mutant tannin deficient seed 4 (tds4-1) has a reduced PA level and altered pattern PA accumulation. We identified the TDS4 gene as LDOX by complementation of the tds4-1 mutation either with a cosmid… CONTINUE READING
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