The Arabidopsis AtPP2CA Protein Phosphatase Inhibits the GORK K+ Efflux Channel and Exerts a Dominant Suppressive Effect on Phosphomimetic-activating Mutations.

@article{Lefoulon2016TheAA,
  title={The Arabidopsis AtPP2CA Protein Phosphatase Inhibits the GORK K+ Efflux Channel and Exerts a Dominant Suppressive Effect on Phosphomimetic-activating Mutations.},
  author={C{\'e}cile Lefoulon and Martin Boeglin and Bertrand Moreau and Anne-Ali{\'e}nor V{\'e}ry and Wojciech Szponarski and Myriam Dauzat and Erwan Michard and Isabelle Gaillard and Isabelle Ch{\'e}rel},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 12},
  pages={6521-33}
}
The regulation of the GORK (Guard Cell Outward Rectifying) Shaker channel mediating a massive K(+) efflux in Arabidopsis guard cells by the phosphatase AtPP2CA was investigated. Unlike the gork mutant, the atpp2ca mutants displayed a phenotype of reduced transpiration. We found that AtPP2CA interacts physically with GORK and inhibits GORK activity in Xenopus oocytes. Several amino acid substitutions in the AtPP2CA active site, including the dominant interfering G145D mutation, disrupted the… CONTINUE READING
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