The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity

@inproceedings{Ng2013TheAE,
  title={The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity},
  author={Chun-Fai Ng and Chun Hay Ko and Chi-Man Koon and Jia-Wen Xian and Ping Chung Leung and K. P. Fung and Ho Y. Chan and Clara Bik-San Lau},
  booktitle={Evidence-based complementary and alternative medicine : eCAM},
  year={2013}
}
This study aims to investigate the neuroprotective effect of the rhizome of Gastrodia elata (GE) aqueous extract on beta-amyloid(A β )-induced toxicity in vivo and in vitro. Transgenic Drosophila mutants with A β -induced neurodegeneration in pan-neuron and ommatidia were used to determine the efficacy of GE. The antiapoptotic and antioxidative mechanisms of GE were also studied in A β -treated pheochromocytoma (PC12) cells. In vivo studies demonstrated that GE (5 mg/g Drosophila media)-treated… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Evaluation of Traditional Medicines for Neurodegenerative Diseases Using Drosophila Models

Evidence-based complementary and alternative medicine : eCAM • 2014
View 5 Excerpts
Highly Influenced

Neuropharmacological Potential of Gastrodia elata Blume and Its Components

Evidence-based complementary and alternative medicine : eCAM • 2015

References

Publications referenced by this paper.
Showing 1-10 of 85 references

Traditional Chinese Medicine for Senile Dementia

Evidence-based complementary and alternative medicine : eCAM • 2012
View 3 Excerpts
Highly Influenced

Konsolaki, “A model for studying Alzheimer’s Aβ42-induced toxicity

A. Finelli, A. Kelkar, H. J. Song, H. Yang
in Drosophilamelanogaster,”Molecular and Cellular Neuroscience, • 2004
View 4 Excerpts
Highly Influenced

Characterization of anti-neurodegenerative effects of Polygala tenuifolia in Aβ(25-35)-treated cortical neurons

R.Naito andC. Tohda
Biological and Pharmaceutical Bulletin, vol. 29, no. 9, pp. 1892–1896, 2006. • 1892
View 3 Excerpts
Highly Influenced

tifunctional microelectrode array ( mMEA ) chip for neural - electrical and neural - chemical interfaces : characterization of comb interdigitated electrode towards dopamine detection

H. Y. Lai, J. A. Annie Ho, Y. Y. Chen
Biosensors and Bioelectronics • 2013

Similar Papers

Loading similar papers…