• Chemistry
  • Published 2010

The Application of Nitrile Hydratases in Organic Synthesis

@inproceedings{Pelt2010TheAO,
  title={The Application of Nitrile Hydratases in Organic Synthesis},
  author={Sander van Pelt},
  year={2010}
}
Nitrile hydratases (NHases, E.C. 4.2.1.84) catalyse the transformation of nitriles into the corresponding amides and were first discovered 30 years ago in studies on the microbial degradation of toxic cyano-group-containing compounds. The use of NHases in synthetic chemistry is especially interesting in conversions where the substrate or the product is labile at the high temperature or extreme pH employed in chemical nitrile hydration. However, also in the production of bulk chemicals like… CONTINUE READING