The Apolipoprotein E (APOE) Gene Appears Functionally Monomorphic in Chimpanzees (Pan troglodytes)

@inproceedings{McIntosh2012TheAE,
  title={The Apolipoprotein E (APOE) Gene Appears Functionally Monomorphic in Chimpanzees (Pan troglodytes)},
  author={Annick M. McIntosh and C. Verity Bennett and Dara Dickson and Stephanie Firos Anestis and David P. Watts and Timothy H. Webster and Mark Fontenot and Brenda J Bradley},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND The human apolipoprotein E (APOE) gene is polymorphic, with three primary alleles (E2, E3, E4) that differ at two key non-synonymous sites. These alleles are functionally different in how they bind to lipoproteins, and this genetic variation is associated with phenotypic variation for several medical traits, including cholesterol levels… CONTINUE READING