The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS.


Apc, a negative regulator of the canonical Wnt signaling pathway, is a bona-fide tumor suppressor whose loss of function results in intestinal polyposis. APC is located in a commonly deleted region on human chromosome 5q, associated with myelodysplastic syndrome (MDS), suggesting that haploinsufficiency of APC contributes to the MDS phenotype. Analysis of… (More)
DOI: 10.1182/blood-2009-11-251728


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