The Apaf-1 apoptosome: a large caspase-activating complex.

@article{Cain2002TheAA,
  title={The Apaf-1 apoptosome: a large caspase-activating complex.},
  author={Kelvin Cain and Shawn B. Bratton and Gerald M. Cohen},
  journal={Biochimie},
  year={2002},
  volume={84 2-3},
  pages={203-14}
}
It is increasingly recognized that many key biological processes, including apoptosis, are carried out within very large multi-protein complexes. Apoptosis can be initiated by activation of death receptors or perturbation of the mitochondria causing the release of apoptogenic proteins, which result in the activation of caspases which are responsible for most of the biochemical and morphological changes observed during apoptosis. Caspases are normally inactive and require proteolytic processing… CONTINUE READING
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