• Corpus ID: 90685808

The Antiviral Properties of Melaleuca alternifolia concentrate (MAC) against West Nile virus

  title={The Antiviral Properties of Melaleuca alternifolia concentrate (MAC) against West Nile virus},
  author={Adriana Pliego-Zamora},


Progress on the development of therapeutics against West Nile virus.
Evasion of innate and adaptive immunity by flaviviruses
Although many of the mechanistic details require further elucidation, flaviviruses have evolved specific tactics to evade the innate and adaptive immune response and a more thorough understanding of these principles could lead to improved models for viral pathogenesis and to strategies for the development of novel antiviral agents.
West Nile Virus Evades Activation of Interferon Regulatory Factor 3 through RIG-I-Dependent and -Independent Pathways without Antagonizing Host Defense Signaling
It is demonstrated that the delayed activation of IRF-3 is essential for WNV-NY to achieve maximum virus production and pathogenic strains of WNV may have evolved to circumvent stimulation of the host response until after replication is well under way.
Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral Evasion
West Nile virus is a neurotropic flavivirus that has emerged globally as a significant cause of viral encephalitis and can also infect and cause disease in horses and other vertebrate animals.
The Dengue Strategic Plan for the Asia Pacific Region 2008-2015, World Health Organization
  • WHO (2009). Dengue Guidelines for Diagnosis Treatment Prevention and Control: New Edition, World Health Organization. WHO (2011). West Nile virus. World Health Organization: Media centre, World Health
  • 2008
CD4+ T-Cell Responses Are Required for Clearance of West Nile Virus from the Central Nervous System
The experiments suggest that the dominant protective role of CD4+ T cells during primary WNV infection is to provide help for antibody responses and sustain WNV-specific CD8+ T-cell responses in the CNS that enable viral clearance.
A cross-protective mAb recognizes a novel epitope within the flavivirus NS1 protein.
It is demonstrated that one of these mAbs (16NS1) cross-reacted with Japanese encephalitis virus (JEV) and exhibited protective activity against a lethal JEV infection.
Dengue and dengue vaccines.
  • R. Edelman
  • Medicine
    The Journal of infectious diseases
  • 2005
The spread of dengue virus from cities to rural areas has impeded the diagnosis and management of DHF/DSS; this, in turn, has resulted in higher case fatality rates, which may be as high as 30% in rural areas, compared with 1% in cities.
Novel approaches to flavivirus drug discovery
The authors discuss recently discovered flavivirus inhibitors with a focus on antivirals targeting non-enzymatic proteins of the dengue virus lifecycle and the need for novel inhibitors and the criteria for successful antiviral drug development.
Yellow fever: 100 years of discovery.
The spread of yellow fever can be most effectually controlled by measures directed to the destruction of mosquitoes, and cannot be transmitted by fomites nor spread in a house without the presence of mosquitoes.