The Antitumorigenic Function of EGFR in Metastatic Breast Cancer is Regulated by Expression of Mig6

@inproceedings{Wendt2015TheAF,
  title={The Antitumorigenic Function of EGFR in Metastatic Breast Cancer is Regulated by Expression of Mig6},
  author={Michael K Wendt and Whitney K. Williams and Pete E. Pascuzzi and Nikolas G. Balanis and Barbara J. Schiemann and Cathleen R. Carlin and William P. Schiemann},
  booktitle={Neoplasia},
  year={2015}
}
Numerous studies by our lab and others demonstrate that epidermal growth factor receptor (EGFR) plays critical roles in primary breast cancer (BC) initiation, growth and dissemination. However, clinical trials targeting EGFR function in BC have lead to disappointing results. In the current study we sought to identify the mechanisms responsible for this disparity by investigating the function of EGFR across the continuum of the metastatic cascade. We previously established that overexpression of… CONTINUE READING
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