Corpus ID: 59407696

The Antioxidative and Antiapoptotic Effects of Chlorophyllin on a Female Rat Spleen Exposed to Localized Gastric Radiotherapy

  title={The Antioxidative and Antiapoptotic Effects of Chlorophyllin on a Female Rat Spleen Exposed to Localized Gastric Radiotherapy},
  author={Ali Me and Gouda Za},
This study evaluated the antioxidative and antiapoptotic effects of chlorophyllin (CHL) on a rat spleen exposed to localized gastric radiotherapy. The stomach region of female rats was exposed to 300 kV X-rays at a dose rate of 2.8 Gy/min either alone or co-treated with oral intake of CHL (15.0 mg kg-1BW) for 4 days. The Catalase (CAT) and Superoxide Dismutase (SOD) activities and Malondialdehyde (MDA) concentrations in the spleen homogenates were conducted. The splenic tissue was examined… Expand

Figures from this paper

Differential Expression of CD3, TNF-α, and VEGF Induced by Olanzapine on the Spleen of Adult Male Albino Rats and the Possible Protective Role of Vitamin C
The administration of vitamin C repaired structural and immunohistochemical changes via increased CD3 and decreased TNF-α and VEGF and the oxidative and the inflammatory pathways may be the possible mechanisms underlying olanzapine immunotoxicity. Expand


Protective role of Vernonia cinerea L. against gamma radiation—induced immunosupression and oxidative stress in mice
There was a synergistic action of radiation and V. cinerea in reducing the solid tumours in mice, indicating its possible use as an adjuvant during radiotherapy. Expand
Effect of chlorophyllin against oxidative stress in splenic lymphocytes in vitro and in vivo.
Results demonstrate antioxidant effect of CHL in vivo and offer protection against whole body irradiation (WBI)-induced lipid peroxidation and apoptosis in lymphocytes at all the time points studied. Expand
Antiapoptotic and immunomodulatory effects of chlorophyllin.
CHL administration to mice immunized with sheep red blood cells (SRBC) augmented both humoral and cell-mediated immune responses, and inhibition of lymphocyte proliferation induced by concanavalin A in a dose dependent manner was examined. Expand
Protective effects of Nasturtium officinale against gamma-irradiation-induced hepatotoxicity in C57 mice
Background and objectivesNasturtium officinale W.T.Aiton (Brassicaceae) is used as an edible vegetable in various parts of Iran. The aim of the present study was to investigate the protectiveExpand
Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene in C57BL/6J mice.
  • D. Gradecka-Meesters, J. Palus, +10 authors M. Stępnik
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
The protective action in C57BL/6J mice from orally administered ellagic acid (EA), benzyl isothiocyanate (BITC), an extract of epigallocatechins (Tegreen®) as well as chlorophyllin (CHL) againstExpand
Amelioration of radiation-induced hematopoietic syndrome by an antioxidant chlorophyllin through increased stem cell activity and modulation of hematopoiesis.
Chlorophyllin mitigates radiation-induced hematopoietic syndrome by increasing the abundance of hematoplastic stem cells, enhancing granulopoiesis, and stimulating prosurvival pathways in bone marrow cells and lymphocytes. Expand
Chlorophyllin in the intrauterine development of mice exposed or not to cyclophosphamide
Chlorophyllin, a sodium-copper salt synthesized from chlorophyll, has already proved to have anticlastogenic, antimutagenic and anticarcinogenic activity, however few are the studies in theExpand
The Antioxidant and Free Radical Scavenging Activities of Chlorophylls and Pheophytins
Chlorophylls are important antioxidants found in foods. We explored the mechanisms through which the a and b forms of chlorophyll and of pheophytin (the Mg-chelated form of chlorophyll) reduceExpand
Dietary Antioxidants Protect Hematopoietic Cells and Improve Animal Survival after Total-Body Irradiation
Oral supplementation with antioxidants appears to be an effective approach for radioprotection of hematopoietic cells and improvement of animal survival, and modulation of apoptosis is implicated as a mechanism for the radioprotsection of the hematopolietic system by antioxidants. Expand
Proteomics analysis of apoptosis-regulating proteins in tissues with different radiosensitivity.
The result suggests that the expression of apoptosis-related protein and redox proteins play important roles in this radiosusceptibility. Expand